NDLI: Enhancing Mechanical Properties and Biological Performances of Injectable Bioactive Glass by Gelatin and Chitosan for Bone Small Defect Repair

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Enhancing Mechanical Properties and Biological Performances of Injectable Bioactive Glass by Gelatin and Chitosan for Bone Small Defect Repair

Content Provider	MDPI
Author	Sohrabi, Mehri Yekta, Bijan Rezaie, Hamidreza Naimi-Jamal, Mohammad Kumar, Ajay Cochis, Andrea Miola, Marta Rimondini, Lia
Copyright Year	2020
Description	Bioactive glass (BG) represents a promising biomaterial for bone healing; here injectable BG pastes biological properties were improved by the addition of gelatin or chitosan, as well as mechanical resistance was enhanced by adding 10 or 20 wt% 3-Glycidyloxypropyl trimethoxysilane (GPTMS) cross-linker. Composite pastes exhibited bioactivity as apatite formation was observed by Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD) after 14 days immersion in simulated body fluid (SBF); moreover, polymers did not enhance degradability as weight loss was >10% after 30 days in physiological conditions. BG-gelatin-20 wt% GPTMS composites demonstrated the highest compressive strength (4.8 ± 0.5 MPa) in comparison with the bulk control paste made of 100% BG in water (1.9 ± 0.1 MPa). Cytocompatibility was demonstrated towards human mesenchymal stem cells (hMSC), osteoblasts progenitors, and endothelial cells. The presence of 20 wt% GPTMS conferred antibacterial properties thus inhibiting the joint pathogens Staphylococcus aureus and Staphylococcus epidermidis infection. Finally, hMSC osteogenesis was successfully supported in a 3D model as demonstrated by alkaline phosphatase release and osteogenic genes expression.
Starting Page	616
e-ISSN	22279059
DOI	10.3390/biomedicines8120616
Journal	Biomedicines
Issue Number	12
Volume Number	8
Language	English
Publisher	MDPI
Publisher Date	2020-12-15
Access Restriction	Open
Subject Keyword	Biomedicines Cell Tissue Engineering Bioactive Glass Gelatin Chitosan 3-glycidyloxypropyl Trimethoxysilane Bone
Content Type	Text
Resource Type	Article

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