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New Generation of Hybrid Materials Based on Gelatin and Bioactive Glass Particles for Bone Tissue Regeneration
| Content Provider | MDPI |
|---|---|
| Author | Houaoui, Amel Szczodra, Agata Lallukka, Mari El-Guermah, Lamia Agniel, Remy Pauthe, Emmanuel Massera, Jonathan Boissiere, Michel |
| Copyright Year | 2021 |
| Description | Hybrid scaffolds based on bioactive glass (BAG) particles (2 was replaced with B2O3)) were introduced in the gelatin matrix. The Cfactor (gelatin/GPTMS molar ratio) was kept constant at 500. The hybrids obtained were found to be stable at 37 °C in solution, the condition in which pure gelatin is liquid. All hybrids were characterized by in vitro dissolution in Tris(hydroxymethyl)aminomethane (TRIS) solution (for up to 4 weeks) and Simulated Body Fluid (SBF) (for up to 2 weeks). Samples processed with 13-93B20 exhibited faster initial dissolution and significantly faster precipitation of a hydroxyapatite (HA) layer. The faster ion release and HA precipitation recorded from the G*/13-93B20 samples are attributable to the higher reactivity of borosilicate compared to silicate glass. The MC3T3-E1 cell behavior in direct contact with the hybrids was investigated, showing that the cells were able to proliferate and spread on the developed biomaterials. Tailoring the glass composition allows us to better control the material’s dissolution, biodegradability, and bioactivity. Bioactive (especially with 13-93B20 BAG) and biocompatible, the hybrids are promising for bone application. |
| Starting Page | 444 |
| e-ISSN | 2218273X |
| DOI | 10.3390/biom11030444 |
| Journal | Biomolecules |
| Issue Number | 3 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-17 |
| Access Restriction | Open |
| Subject Keyword | Biomolecules Cell Tissue Engineering Hybrid Scaffold Bioactive Glass Gelatin Gptms Bone Tissue Engineering |
| Content Type | Text |
| Resource Type | Article |
