NDLI: Hydrolyzed Chicken Extract $(ProBeptigen^{®}$) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial

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Hydrolyzed Chicken Extract $(ProBeptigen^{®}$) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial

Content Provider	MDPI
Author	Wu, Dean Yang, Cheng-Chang Chen, Kuan-Yu Lin, Ying-Chin Wu, Pei-Jung Hsieh, Pei-Hsiu Nakao, Yoshihiro Ow, Mandy Hsieh, Yi-Chen Hu, Chaur-Jong
Copyright Year	2020
Description	Cognitive decline is an important issue of global public health. Cognitive aging might begin at middle adulthood, the period particularly vulnerable to stress in lifespan. Essence of chicken (EOC) has consistently demonstrated its beneficial effects on various cognitive domains as nutritional supplementation. This study primarily aimed to examine the cognitive enhancement effects of $ProBeptigen^{®}$ (previously named CMI-168), hydrolyzed peptides extracted from EOC, in healthy middle-aged people under mild stress. Ninety healthy subjects were randomly assigned into the $ProBeptigen^{®}$ or placebo group for eight weeks. Neurocognitive assessment, event-related potentials (ERPs), and blood tests were conducted before, during, and after the treatment. The $ProBeptigen^{®}$ group outperformed placebo group on Logical Memory subtests of Wechsler Memory Scale-third edition (WMS-III) and Spatial Working Memory task in the Cambridge Neuropsychological Test Automated Battery (CANTAB). The anti-inflammatory effects of $ProBeptigen^{®}$ in humans were also confirmed, with progressively declining high-sensitivity C-reactive protein (hs-CRP) levels. Regular dietary supplementation of $ProBeptigen^{®}$ is suggested to improve verbal short- and long-term memory as well as spatial working memory, and reduce inflammation in middle-aged healthy individuals with stress. The effects of $ProBeptigen^{®}$ on cognition warrant further investigation. (NCT03612752)
Starting Page	1362
e-ISSN	20726643
DOI	10.3390/nu12051362
Journal	Nutrients
Issue Number	5
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2020-05-10
Access Restriction	Open
Subject Keyword	Nutrients Gerontology Dietary Supplements Cognitive Decline Essence of Chicken
Content Type	Text
Resource Type	Article

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