NDLI: Effects of Ferulic Acid and <i>Angelica archangelica</i> Extract (Feru-guard<sup> ®</sup>) on Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Prospective Trial.

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Effects of Ferulic Acid and Angelica archangelica Extract (Feru-guard^®) on Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Prospective Trial.

Content Provider	Europe PMC
Author	Kudoh, Chiaki Hori, Tomokatsu Yasaki, Shunji Ubagai, Ryu Tabira, Takeshi
Copyright Year	2020
Abstract	We conducted a multicenter, randomized, double-blind, placebo-controlled prospective trial examining a supplement containing ferulic acid and Angelica archangelica extract (Feru-guard ®) for mild cognitive impairment (MCI). In the intention-to-treat population, Mini-Mental State Examination (MMSE) scores were significantly better at 24 weeks (p = 0.041) in the active group. In the per protocol population, MMSE was significantly better in the active group at 24 weeks (p = 0.008), and mixed effect models for repeated measures (MMRM) showed significant difference (p = 0.016). ADAS-Jcog was significantly better at 24 (p = 0.035) and 48 weeks (p = 0.015) in the active group, and MMRM was significant (p = 0.031). Thus, Feru-guard ® may be useful for MCI.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7592837&blobtype=pdf
Journal	Journal of Alzheimer's Disease Reports [J Alzheimers Dis Rep]
Volume Number	4
PubMed Central reference number	PMC7592837
Issue Number	1
PubMed reference number	33163900
e-ISSN	25424823
DOI	10.3233/adr-200211
Language	English
Publisher	IOS Press
Publisher Date	2020-09-18
Publisher Place	Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License. © 2020 – IOS Press and the authors. All rights reserved
Subject Keyword	Angelica archangelica dementia dietary supplement double-blind randomized trial ferulic acid mild cognitive impairment
Content Type	Text
Resource Type	Article
Subject	Geriatrics and Gerontology Clinical Psychology Neuroscience Psychiatry and Mental Health

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Effects of Ferulic Acid and Angelica archangelica Extract (Feru-guard ®) on Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Prospective Trial.

Effects of Ferulic Acid and Angelica archangelica Extract (Feru-guard^®) on Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Prospective Trial.