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The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients
| Content Provider | MDPI |
|---|---|
| Author | Dominika, Dęborska-Materkowska Dorota, Kamińska |
| Copyright Year | 2021 |
| Description | Since its outbreak in December 2019, the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to an enormous rise in scientific response with an excess of COVID-19-related studies on the pathogenesis and potential therapeutic approaches. Solid organ transplant (SOT) recipients are a heterogeneous population with long-lasting immunosuppression as a joining element. Immunocompromised patients are a vulnerable population with a high risk of severe infections and an increased infection-related mortality rate. It was postulated that the hyperinflammatory state due to cytokine release syndrome during severe COVID-19 could be alleviated by immunosuppressive therapy in SOT patients. On the other hand, it was previously established that T cell-mediated immunity, which is significantly weakened in SOT recipients, is the main component of antiviral immune responses. In this paper, we present the current state of science on COVID-19 immunology in relation to solid organ transplantation with prospective therapeutic and vaccination strategies in this population. |
| Starting Page | 1879 |
| e-ISSN | 19994915 |
| DOI | 10.3390/v13091879 |
| Journal | Viruses |
| Issue Number | 9 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-09-20 |
| Access Restriction | Open |
| Subject Keyword | Viruses Solid Organ Transplant Recipients Covid-19 Cellular Immunity Humoral Immunity Vaccination |
| Content Type | Text |
| Resource Type | Article |
