NDLI: Impaired Humoral Response in Renal Transplant Recipients to SARS-CoV-2 Vaccination with BNT162b2 (Pfizer-BioNTech)

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Impaired Humoral Response in Renal Transplant Recipients to SARS-CoV-2 Vaccination with BNT162b2 (Pfizer-BioNTech)

Content Provider	MDPI
Author	Burkhard, Sorge-Hädicke Anja, Gäckler Korth, Johannes Jahn, Michael Dorsch, Oliver Anastasiou, Olympia Eisenberger, Ute Dittmer, Ulf Witzke, Oliver Wilde, Benjamin Dolff, Sebastian Kribben, Andreas
Copyright Year	2021
Description	The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has a major impact on transplant recipients, with mortality rates up to 20%. Therefore, the effect of established messenger RNA (mRNA)-based SARS-CoV-2 vaccines have to be evaluated for solid organ transplant patients (SOT) since they are known to have poor responses after vaccination. We investigated the SARS-CoV-2 immune response via SARS-CoV-2 IgG detection in 23 renal transplant recipients after two doses of the mRNA-based SARS-CoV-2 vaccine BNT162b2 following the standard protocol. The antibody response was evaluated once with an anti-SARS-CoV-2 IgG CLIA 15.8 +/− 3.0 days after the second dose. As a control, SARS-CoV-2 IgG was determined in 23 healthcare workers (HCW) and compared to the patient cohort. Only 5 of 23 (22%) renal transplant recipients were tested positive for SARS-CoV-2 IgG antibodies after the second dose of vaccine. In contrast, all 23 (100%) HCWs were tested positive for antibodies after the second dose. Thus, the humoral response of renal transplant recipients after two doses of the mRNA-based vaccine BNT162b2 (Pfizer-BioNTech, Kronach, Germany) is impaired and significantly lower compared to healthy controls (22% vs. 100%; p = 0.0001). Individual vaccination strategies might be beneficial in these vulnerable patients.
Starting Page	756
e-ISSN	19994915
DOI	10.3390/v13050756
Journal	Viruses
Issue Number	5
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-04-25
Access Restriction	Open
Subject Keyword	Viruses Transplantation Sars-cov-2 Vaccination Renal Transplant Recipients Renal Transplantation Covid-19
Content Type	Text
Resource Type	Article

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