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Recovery of Innate Immune Cells and Persisting Alterations in Adaptive Immunity in the Peripheral Blood of Convalescent Plasma Donors at Eight Months Post SARS-CoV-2 Infection
| Content Provider | MDPI |
|---|---|
| Author | Kostopoulos, Ioannis Orologas-Stavrou, Nikolaos Rousakis, Pantelis Panteli, Chrysanthi Ntanasis-Stathopoulos, Ioannis Charitaki, Ioanna Korompoki, Eleni Gavriatopoulou, Maria Kastritis, Efstathios Trougakos, Ioannis Dimopoulos, Meletios-Athanasios Tsitsilonis, Ourania Terpos, Evangelos |
| Copyright Year | 2021 |
| Description | Persisting alterations and unique immune signatures have been previously detected in the peripheral blood of convalescent plasma (CP) donors at approximately two months after initial SARS-CoV-2 infection. This article presents the results on the sequential analysis of 47 CP donors at a median time of eight months (range 7.5–8.5 months) post infection, as assessed by flow cytometry. Interestingly, our results show a significant variation of the relevant immune subset composition among CP donors. Regarding innate immunity, both non-classical monocytes, and CD11b- granulocytes had fully recovered at eight months post COVID-19 infection. Intermediate monocytes and natural killer (NK) cells had already been restored at the two-month evaluation and remained stable. Regarding adaptive immunity, the COVID-19-related skewed Th1 and Th2 cell polarization remained at the same levels as in two months. However, low levels of total B cells were detected even after eight months from infection. A persisting reduction of CD8+ Tregs and changes in the NKT cell compartment were also remarkable. CP donors present with a unique immune landscape at eight months post COVID-19 infection, which is characterized by the notable restoration of the components of innate immunity along with a persisting imprint of SARS-CoV-2 in cells of the adaptive immunity. |
| Starting Page | 546 |
| e-ISSN | 20762607 |
| DOI | 10.3390/microorganisms9030546 |
| Journal | Microorganisms |
| Issue Number | 3 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-06 |
| Access Restriction | Open |
| Subject Keyword | Microorganisms Immunology Sars-cov-2 Covid-19 Convalescence Plasma Donors Immune Profiling Immune Restoration 8 Months |
| Content Type | Text |
| Resource Type | Article |
