Loading...
Please wait, while we are loading the content...
Similar Documents
Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review
| Content Provider | MDPI |
|---|---|
| Author | Sivasudhan, Enakshi Blake, Neil Lu, Zhiliang Meng, Jia Rong, Rong |
| Copyright Year | 2022 |
| Description | With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X protein (HBx), a key multifunctional regulatory protein, drives viral replication and interferes with several cellular signalling pathways that drive virus-associated hepatocarcinogenesis. This review article provides a comprehensive overview of the role of HBx in modulating the various hallmarks of HCC by supporting tumour initiation, progression, invasion and metastasis. Understanding HBx-mediated dimensions of complexity in driving liver malignancies could provide the key to unlocking novel and repurposed combinatorial therapies to combat HCC. |
| Starting Page | 741 |
| e-ISSN | 20734409 |
| DOI | 10.3390/cells11040741 |
| Journal | Cells |
| Issue Number | 4 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-02-21 |
| Access Restriction | Open |
| Subject Keyword | Cells Gastroenterology and Hepatology Hepatitis B Virus Hbx Protein Hepatocellular Carcinoma Cancer Hallmarks Therapeutics |
| Content Type | Text |
| Resource Type | Article |