NDLI: Chitosan Oligosaccharides Suppress Nuclear Factor-Kappa B Activation and Ameliorate Experimental Autoimmune Uveoretinitis in Mice

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Chitosan Oligosaccharides Suppress Nuclear Factor-Kappa B Activation and Ameliorate Experimental Autoimmune Uveoretinitis in Mice

Content Provider	MDPI
Author	Hsu, Sheng-Min Yang, Chang-Hao Tsai, Hsien-Yang Lin, Chia-Jhen Fang, Yi-Hsuan Shieh, Chi-Chang Chen, Shun-Hua
Copyright Year	2020
Description	We investigated the therapeutic potential and mechanism of chitosan oligosaccharides (COS) for experimental autoimmune uveoretinitis (EAU) in mice. EAU was induced in C57/BL6 mice by injection of human interphotoreceptor retinoid-binding protein (IRBP) peptides. At the same time, a high or low dose (20 or 10 mg/kg) of COS or phosphate-buffered saline (PBS) was given to mice daily after EAU induction. We found that mouse EAU is ameliorated by the high-dose COS treatment when compared with PBS treatment. In the retinas of high-dose COS-treated mice, the nuclear translocation of NF-κB subunit (p65) was suppressed, and the expression of several key EAU inflammatory mediators, IFN-γ, TNF-α, IL-1α, IL-4, IL-5, IL-6, IL-10, IL-17 and MCP-1 was lowered. These results suggest that COS may be a potential treatment for posterior uveitis.
Starting Page	8326
e-ISSN	14220067
DOI	10.3390/ijms21218326
Journal	International Journal of Molecular Sciences
Issue Number	21
Volume Number	21
Language	English
Publisher	MDPI
Publisher Date	2020-11-06
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Pathology Chitosan Oligosaccharides (cos) Experimental Autoimmune Uveoretinitis (eau) Nuclear Factor-kappa B (nf-κb)
Content Type	Text
Resource Type	Article

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