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The Role of Nuclear Factor Kappa B (NF-κB) in Development and Treatment of COVID-19: Review
| Content Provider | MDPI |
|---|---|
| Author | Gudowska-Sawczuk, Monika Mroczko, Barbara |
| Copyright Year | 2022 |
| Description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 19 (COVID-19), a disease that has affected more than 500 million people worldwide since the end of 2019. Due to its high complications and death rates, there is still a need to find the best therapy for SARS-CoV-2 infection. The dysregulation of the inflammatory response in COVID-19 plays a very important role in disease progression. It has been observed that abnormal activity of Nuclear Factor kappa B (NF-κB) is directly associated with, inter alia, increased synthesis of proinflammatory factors. Therefore, this review paper focuses on the functions of NF-κB in the development of SARS-CoV-2 infection and potential application of NF-κB inhibitors in COVID-19 immunotherapy. A comprehensive literature search was performed using the MEDLINE/PubMed database. In the current review, it is highlighted that NF-κB plays important functions in the modulation of an adaptive inflammatory response, including inducing the expression of proinflammatory genes. Increased activation of NF-κB in SARS-CoV-2 infection was observed. The association between NF-κB activation and the expression of SARS-CoV-2 structural and non-structural proteins were also reported. It was observed that modulation of NF-κB using, e.g., traditional Chinese medicine or glucocorticosteroids resulted in decreased synthesis of proinflammatory factors caused by SARS-CoV-2 infection. This review summarizes the role of NF-κB in COVID-19 and describes its potential immunotherapeutic target in treatment of SARS-CoV-2 infection. However, indisputably more studies involving patients with a severe course of COVID-19 are sorely needed. |
| Starting Page | 5283 |
| e-ISSN | 14220067 |
| DOI | 10.3390/ijms23095283 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 9 |
| Volume Number | 23 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-05-09 |
| Access Restriction | Open |
| Subject Keyword | International Journal of Molecular Sciences Integrative and Complementary Medicine Sars-cov-2 Covid-19 Inflammation Nuclear Factor Kappa B (nf-κb) Inflammatory Factors |
| Content Type | Text |
| Resource Type | Article |
