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Ugi Reaction on α-Phosphorated Ketimines for the Synthesis of Tetrasubstituted α-Aminophosphonates and Their Applications as Antiproliferative Agents
| Content Provider | MDPI |
|---|---|
| Author | Adri, án López-Francés Corte, Xabier del de Marigorta, Edorta Martínez Palacios, Francisco Vicario, Javier |
| Copyright Year | 2021 |
| Description | An Ugi three-component reaction using preformed α-phosphorated N-tosyl ketimines with different isocyanides in the presence of a carboxylic acid affords tetrasubstituted α-aminophosphonates. Due to the high steric hindrance, the expected acylated amines undergo a spontaneous elimination of the acyl group. The reaction is applicable to α-aryl ketimines bearing a number of substituents and several isocyanides. In addition, the densely substituted α-aminophosphonate substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell line A549 (carcinomic human alveolar basal epithelial cell). |
| Starting Page | 1654 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules26061654 |
| Journal | Molecules |
| Issue Number | 6 |
| Volume Number | 26 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-16 |
| Access Restriction | Open |
| Subject Keyword | Molecules Organic Chemistry Multicomponent Synthesis Ugi Reaction Α-aminophosphonates Tetrasubstituted Carbons Antiproliferative Effect |
| Content Type | Text |
| Resource Type | Article |
