NDLI: Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects

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Aristolochia trilobata: Identification of the Anti-Inflammatory and Antinociceptive Effects

Content Provider	MDPI
Author	Dayana, Da Costa Salomé Tayn, á Sequeira Valério Cordeiro, Natália De Moraes Santos, Darlisson Alves, Péricles Barreto Alviano, Celuta Sales Moreno, Daniela Sales Alviano Fernandes, Patricia Dias
Copyright Year	2020
Description	Aristolochia trilobata, popularly known as “mil-homens,” is widely used for treatment of stomach aches, colic, asthma, pulmonary diseases, diabetes, and skin affection. We evaluated the antinociceptive and anti-inflammatory activities of the essential oil (EO) and the main constituent, 6-methyl-5-hepten-2-yl acetate (sulcatyl acetate, SA). EO and SA (1, 10, and 100 mg/kg, p.o.) were evaluated using chemical (formalin-induced licking) and thermal (hot-plate) models of nociception or inflammation (carrageenan-induced cell migration into the subcutaneous air pouch, SAP). The mechanism of antinociceptive activity was evaluated using opioid, cholinergic receptor antagonists (naloxone and atropine), or nitric oxide synthase inhibitor (L-NAME). EO and SA presented a central antinociceptive effect (the hot-plate model). In formalin-induced licking response, higher doses of EO and SA also reduced 1st and 2nd phases. None of the antagonists and enzyme inhibitor reversed antinociceptive effects. EO and SA reduced the leukocyte migration into the SAP, and the cytokines tumor necrosis factor and interleukin-1 (TNF-α and IL-1β, respectively) produced in the exudate. Our results are indicative that EO and SA present peripheral and central antinociceptive and anti-inflammatory effects.
Starting Page	111
e-ISSN	22279059
DOI	10.3390/biomedicines8050111
Journal	Biomedicines
Issue Number	5
Volume Number	8
Language	English
Publisher	MDPI
Publisher Date	2020-05-06
Access Restriction	Open
Subject Keyword	Biomedicines Integrative and Complementary Medicine Aristolochia Trilobata Sulcatyl Acetate Antinociceptive Effect Anti-inflammatory Activity
Content Type	Text
Resource Type	Article

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