NDLI: Antinociceptive and Anti-Inflammatory Activities of Limonin Isolated from the Fruits ofEvodia rutaecarpavar.bodinieri

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Antinociceptive and Anti-Inflammatory Activities of Limonin Isolated from the Fruits ofEvodia rutaecarpavar.bodinieri

Content Provider	Scilit
Author	Matsuda, H. Yoshikawa, M. Linuma, M. Kubo, M.
Copyright Year	1998
Description	Antinociceptive and anti-inflammatory effects of limonin isolated from the dried fruits of Evodia rutaecarpa var. bodinieri were investigated. Oral administration of 30 or 100mg/kg limonin significantly decreased the frequency of licking and biting behavior within a unit of time at the late phase without affecting that of the early phase in the formalin test. Limonin inhibited the rise of vascular permeability induced by acetic acid and the increase of paw edema induced by carrageenin. Limonin also showed inhibitory effects on bradykinin induced paw edema and arachidonic acid-induced ear swelling. These results suggest that limonin possesses an antinociceptive effect and the effect may be accompanied by an anti-inflammatory action, and that the antinociceptive activity in Evodiae Fructus is partially attributable to limonin.
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-957447.pdf
Ending Page	342
Page Count	4
Starting Page	339
ISSN	00320943
e-ISSN	14390221
DOI	10.1055/s-2006-957447
Journal	Planta Medica
Issue Number	04
Volume Number	64
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	1998-05-01
Access Restriction	Open
Subject Keyword	Journal: Planta Medica Integrative and Complementary Medicine Evodia Rutaecarpa Var. Bodinieri Evodiae Fructus Antinociceptive Activity Anti-inflammatory Activity
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Analytical Chemistry Molecular Medicine Pharmacology Complementary and Alternative Medicine Pharmaceutical Science

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