NDLI: Nutritional Regulation of Human Brown Adipose Tissue

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Nutritional Regulation of Human Brown Adipose Tissue

Content Provider	MDPI
Author	Suchacki, Karla Stimson, Roland
Copyright Year	2021
Description	The recent identification of brown adipose tissue in adult humans offers a new strategy to increase energy expenditure to treat obesity and associated metabolic disease. While white adipose tissue (WAT) is primarily for energy storage, brown adipose tissue (BAT) is a thermogenic organ that increases energy expenditure to generate heat. BAT is activated upon cold exposure and improves insulin sensitivity and lipid clearance, highlighting its beneficial role in metabolic health in humans. This review provides an overview of BAT physiology in conditions of overnutrition (obesity and associated metabolic disease), undernutrition and in conditions of altered fat distribution such as lipodystrophy. We review the impact of exercise, dietary macronutrients and bioactive compounds on BAT activity. Finally, we discuss the therapeutic potential of dietary manipulations or supplementation to increase energy expenditure and BAT thermogenesis. We conclude that chronic nutritional interventions may represent a useful nonpharmacological means to enhance BAT mass and activity to aid weight loss and/or improve metabolic health.
Starting Page	1748
e-ISSN	20726643
DOI	10.3390/nu13061748
Journal	Nutrients
Issue Number	6
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-05-21
Access Restriction	Open
Subject Keyword	Nutrients Nutrition and Dietetics Brown Adipose Tissue Obesity Type 2 Diabetes Dietary (calorie) Restriction Nutrition Energy Expenditure
Content Type	Text
Resource Type	Article

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