Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus.

Content Provider	Europe PMC
Author	Cheng, Long Wang, Jingkang Dai, Hongyu Duan, Yuhui An, Yongcheng Shi, Lu Lv, Yinglan Li, Huimin Wang, Chen Ma, Quantao Li, Yaqi Li, Pengfei Du, Haifeng Zhao, Baosheng
Copyright Year	2021
Abstract	ABSTRACTMammalian adipose tissue can be divided into two major types, namely, white adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a thermogenic tissue that acts a pivotal part in maintaining the core body temperature. White adipocytes display high plasticity and can transdifferentiate into beige adipocytes which have many similar morphological and functional properties with brown adipocytes under the stimulations of exercise, cold exposure and other factors. This phenomenon is also known as ‘browning of WAT’. In addition to transdifferentiation, beige adipocytes can also come from de novo differentiation from tissue-resident progenitors. Activating BAT and inducing browning of WAT can accelerate the intake of glycolipids and reduce the insulin secretion requirement, which may be a new strategy to improve glycolipids metabolism and insulin resistance of obese and type 2 diabetes mellitus (T2DM) patients. This review mainly discusses the significance of brown and beige adipose tissues in the treatment of obesity and T2DM, and focuses on the effect of the browning agent on obesity and T2DM, which provides a brand-new theoretical reference for the prevention and treatment of obesity and T2DM.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7801117&blobtype=pdf
Page Count	18
ISSN	21623945
Journal	Adipocyte
Volume Number	10
DOI	10.1080/21623945.2020.1870060
PubMed Central reference number	PMC7801117
Issue Number	1
PubMed reference number	33403891
e-ISSN	2162397X
Language	English
Publisher	Taylor & Francis
Publisher Date	2021-12-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Subject Keyword	Brown adipose tissue beige adipose tissue white adipose tissue browning of white adipose tissue obesity type 2 diabetes mellitus
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology