NDLI: Overcoming Multidrug Resistance of Antibiotics via Nanodelivery Systems

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Overcoming Multidrug Resistance of Antibiotics via Nanodelivery Systems

Content Provider	MDPI
Author	Imran, Mohammad Jha, Saurav Kumar Hasan, Nazeer Insaf, Areeba Shrestha, Jitendra Shrestha, Jesus Devkota, Hari Prasad Khan, Salman Panth, Nisha Warkiani, Majid Ebrahimi Dua, Kamal Hansbro, Philip M. Paudel, Keshav Raj Mohammed, Yousuf
Copyright Year	2022
Description	Antibiotic resistance has become a threat to microbial therapies nowadays. The conventional approaches possess several limitations to combat microbial infections. Therefore, to overcome such complications, novel drug delivery systems have gained pharmaceutical scientists’ interest. Significant findings have validated the effectiveness of novel drug delivery systems such as polymeric nanoparticles, liposomes, metallic nanoparticles, dendrimers, and lipid-based nanoparticles against severe microbial infections and combating antimicrobial resistance. This review article comprises the specific mechanism of antibiotic resistance development in bacteria. In addition, the manuscript incorporated the advanced nanotechnological approaches with their mechanisms, including interaction with the bacterial cell wall, inhibition of biofilm formations, activation of innate and adaptive host immune response, generation of reactive oxygen species, and induction of intracellular effect to fight against antibiotic resistance. A section of this article demonstrated the findings related to the development of delivery systems. Lastly, the role of microfluidics in fighting antimicrobial resistance has been discussed. Overall, this review article is an amalgamation of various strategies to study the role of novel approaches and their mechanism to fight against the resistance developed to the antimicrobial therapies.
Starting Page	586
e-ISSN	19994923
DOI	10.3390/pharmaceutics14030586
Journal	Pharmaceutics
Issue Number	3
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2022-03-08
Access Restriction	Open
Subject Keyword	Pharmaceutics Microbiology Antimicrobial Resistance Drug Delivery Resistance Mechanism Microfluidics Nanoparticles Lipid-based Nanocarriers
Content Type	Text
Resource Type	Article

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