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Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance
| Content Provider | MDPI |
|---|---|
| Author | Emmanuelle, Dé Le, Hung Karakasyan, Carole Jouenne, Thierry Cerf, Didier Le |
| Copyright Year | 2021 |
| Description | Antimicrobial resistance is one of the greatest threats to global health. Although the efforts in antibiotic drug discovery continue to play a pivotal role, this solution alone probably will not be enough to ensure the required level of infection control in the future. New strategies and innovative modes of action are desperately needed to preserve the effectiveness of antimicrobials. Accordingly, antibiotic delivery based on polymeric nanoparticles is one of the possible methods that has been recently explored to improve their pharmacokinetic profile. Through optimized access of antibiotics to their sites of action, nanocarriers can unlock the full potential of the antibiotic cargoes, extend the antimicrobial spectrum, and reduce the required dose of antibiotic while preserving efficacy. Additionally, the use of an antibiotic-loaded nanocarrier is also considered a steady solution as novel molecules can be continuously developed and incorporated into the delivery platform. This review describes the present state of polymeric nanocarriers in enhancing antibiotic treatment, including improved pharmacokinetic properties and restored antibiotic efficacy against drug-resistant bacteria. Additionally, the current challenges and the future direction of this field are discussed. |
| Starting Page | 10695 |
| e-ISSN | 20763417 |
| DOI | 10.3390/app112210695 |
| Journal | Applied Sciences |
| Issue Number | 22 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-11-12 |
| Access Restriction | Open |
| Subject Keyword | Applied Sciences Microbiology Antimicrobial Resistance Polymeric Nanocarrier Antibiotic Local Bioavailability Controlled Release Targeted Delivery Co-delivery Antibiotic Combination |
| Content Type | Text |
| Resource Type | Article |
