NDLI: Chemical Composition, Biological Activities and In Silico Analysis of Essential Oils of Three Endemic Prangos Species from Turkey

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Chemical Composition, Biological Activities and In Silico Analysis of Essential Oils of Three Endemic Prangos Species from Turkey

Content Provider	MDPI
Author	Evren, Yıldıztugay Stefano, Dall’Acqua Zengin, Gokhan Mahomoodally, Mohamad Fawzi Jugreet, Sharmeen Khan, Shafi Ullah Mollica, Adriano Bouyahya, Abdelhakim Montesano, Domenico
Copyright Year	2022
Description	In this study, the essential oils (EOs) obtained from three endemic Prangos species from Turkey (P. heyniae, P. meliocarpoides var. meliocarpoides, and P. uechtritzii) were studied for their chemical composition and biological activities. β-Bisabolenal (12.2%) and caryophyllene oxide (7.9%) were the principal components of P. heyniae EO, while P. meliocarpoides EO contained sabinene (16.7%) and p-cymene (13.2%), and P. uechtritzii EO contained p-cymene (24.6%) and caryophyllene oxide (19.6%), as the most abundant components. With regard to their antioxidant activity, all the EOs were found to possess free radical scavenging potential demonstrated in both DPPH and ABTS assays (0.43–1.74 mg TE/g and 24.18–92.99 mg TE/g, respectively). Additionally, while no inhibitory activity was displayed by P. meliocarpoides and P. uechtritzii EOs against both cholinesterases (acetyl- and butyryl-cholinesterases). Moreover, all the EOs were found to act as inhibitors of tyrosinase (46.34–69.56 mg KAE/g). Molecular docking revealed elemol and α-bisabolol to have the most effective binding affinity with tyrosinase and amylase. Altogether, this study unveiled some interesting biological activities of these EOs, especially as natural antioxidants and tyrosinase inhibitors and hence offers stimulating prospects of them in the development of anti-hyperpigmentation topical formulations.
Starting Page	1676
e-ISSN	14203049
DOI	10.3390/molecules27051676
Journal	Molecules
Issue Number	5
Volume Number	27
Language	English
Publisher	MDPI
Publisher Date	2022-03-03
Access Restriction	Open
Subject Keyword	Molecules Integrative and Complementary Medicine Prangos Essential Oil Chemical Composition Antioxidant Enzyme Inhibition Molecular Docking
Content Type	Text
Resource Type	Article

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