NDLI: Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species Croton ferrugineus and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity

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Chemical Constituents of the Essential Oil from Ecuadorian Endemic Species Croton ferrugineus and Its Antimicrobial, Antioxidant and α-Glucosidase Inhibitory Activity

Content Provider	MDPI
Author	Valarezo, Eduardo Gaona-Granda, Génesis Morocho, Vladimir Cartuche, Luis Calva, James Meneses, Miguel
Copyright Year	2021
Description	Croton ferrugineus Kunth is an endemic species of Ecuador used in traditional medicine both for wound healing and as an antiseptic. In this study, fresh Croton ferrugineus leaves were collected and subjected to hydrodistillation for extraction of the essential oil. The chemical composition of the essential oil was determined by gas chromatography equipped with a flame ionization detector and gas chromatography coupled to a mass spectrometer using a non-polar and a polar chromatographic column. The antibacterial activity was assayed against three Gram-positive bacteria, one Gram-negative bacterium and one dermatophyte fungus. The radical scavenging properties of the essential oil was evaluated by means of DPPH and ABTS assays. The chemical analysis allowed us to identify thirty-five compounds representing more than 99.95% of the total composition. Aliphatic sesquiterpene hydrocarbon trans-caryophyllene was the main constituent with 20.47 ± 1.25%. Other main compounds were myrcene (11.47 ± 1.56%), β-phellandrene (10.55 ± 0.02%), germacrene D (7.60 ± 0.60%), and α-humulene (5.49 ± 0.38%). The essential oil from Croton ferrugineus presented moderate activity against Candida albicans (ATCC 10231) with an MIC of 1000 μg/mL, a scavenging capacity $SC_{50}$ of 901 ± 20 µg/mL with the ABTS method, and very strong antiglucosidase activity with an $IC_{50}$ of 146 ± 20 µg/mL.
Starting Page	4608
e-ISSN	14203049
DOI	10.3390/molecules26154608
Journal	Molecules
Issue Number	15
Volume Number	26
Language	English
Publisher	MDPI
Publisher Date	2021-07-29
Access Restriction	Open
Subject Keyword	Molecules Integrative and Complementary Medicine Croton Ferrugineus Essential Oil Chemical Composition Antiglucosidase Activity Antimicrobial Activity Antioxidant Activity
Content Type	Text
Resource Type	Article

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