NDLI: LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression

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LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression

Content Provider	MDPI
Author	Tang, Philip Chiu-Tsun Zhang, Ying-Ying Li, Jane Siu-Fan Chan, Max Kam-Kwan Chen, Jiaoyi Tang, Ying Zhou, Yiming Zhang, Dongmei Leung, Kam-Tong To, Ka-Fai Tang, Sydney Chi-Wai Lan, Hui-Yao Tang, Patrick Ming-Kuen
Copyright Year	2022
Description	Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibroblast generation and kidney cell activation. In cancer, TGF-β promotes cancer invasion and metastasis by enhancing the stemness and epithelial mesenchymal transition of cancer cells. However, TGF-β is highly pleiotropic in both tissue fibrosis and cancers, and thus, direct targeting of TGF-β may also block its protective anti-inflammatory and tumor-suppressive effects, resulting in undesirable outcomes. Increasing evidence suggests the involvement of long non-coding RNAs (lncRNAs) in TGF-β-driven tissue fibrosis and cancer progression with a high cell-type and disease specificity, serving as an ideal target for therapeutic development. In this review, the mechanism and translational potential of TGF-β-associated lncRNAs in tissue fibrosis and cancer will be discussed.
Starting Page	36
e-ISSN	2311553X
DOI	10.3390/ncrna8030036
Journal	Non-Coding RNA
Issue Number	3
Volume Number	8
Language	English
Publisher	MDPI
Publisher Date	2022-05-25
Access Restriction	Open
Subject Keyword	Non-Coding RNA Non-coding Rna Oncology Long Non-coding Rna Fibrosis Transforming Growth Factor-β Cancer Smad3 Tgf-β
Content Type	Text
Resource Type	Article

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