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Poly(Ethylene Glycol)-Poly(l-Alanine)/Hyaluronic Acid Complex as a 3D Platform for Understanding Cancer Cell Migration in the Tumor Microenvironment
| Content Provider | MDPI |
|---|---|
| Author | Sim, Jooyoung Lee, Hyun Jeong, Byeongmoon Park, Min |
| Copyright Year | 2021 |
| Description | Cancer progression and migration in the tumor microenvironment are related to cell types and three-dimensional (3D) matrices. Therefore, developing biomimetic tumor models, including co-culture systems and a tunable 3D matrix, could play an essential role in understanding the cancer environment. Here, multicellular spheroids using human adipose-derived mesenchymal stem cells (hADSCs) and breast cancer cells (MDA-MB-231) within the 3D matrix were used as a tumor microenvironment (TME) mimicking platform. The amphiphilic peptide block copolymer and hyaluronic acid (HA) formed a self-assembled structure, which provides a biocompatible 3D environment for the cells. Multicellular spheroids were formed on the optimized plate and were observed as cell migration from a spheroid within a 3D matrix, such as the invasive and metastatic cancer of TME. This study suggests a new 3D platform using polymer complexes and the importance of tumor complexities, including various cell types and microenvironments. |
| Starting Page | 1042 |
| e-ISSN | 20734360 |
| DOI | 10.3390/polym13071042 |
| Journal | Polymers |
| Issue Number | 7 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-26 |
| Access Restriction | Open |
| Subject Keyword | Polymers Biomaterials Tumor Microenvironment 3d Matrix Multicellular Spheroid Polymer Complex Migration |
| Content Type | Text |
| Resource Type | Article |
