Loading...
Please wait, while we are loading the content...
Fabrication of Poly(ethylene glycol) Capsules via Emulsion Templating Method for Targeted Drug Delivery
| Content Provider | MDPI |
|---|---|
| Author | Yang, Shuang Ding, Feng Gao, Zhiliang Guo, Jianman Cui, Jiwei Zhang, Peiyu |
| Copyright Year | 2020 |
| Description | To reduce nonspecific interactions and circumvent biological barriers, low-fouling material of poly(ethylene glycol) (PEG) is most used for the modification of drug nanocarriers. Herein, we report the fabrication of PEG capsules via the free-radical polymerization of linear PEG or 8-arm-PEG using an emulsion templating method for targeted drug delivery. Doxorubicin (DOX) could be loaded in capsules via electrostatic interactions. The obtained capsules composed of 8-arm-PEG result in a lower cell association (2.2%) compared to those composed of linear PEG (7.3%) and, therefore, demonstrate the stealth property. The functionalization of cyclic peptides containing Arg-Gly-Asp (cRGD) on PEG capsules induce high cell targeting to U87 MG cells. A cell cytotoxicity assay demonstrates the biocompatibility of PEG capsules and high drug delivery efficacy of the targeted capsules. The reported capsules with the stealth and targeting property provide a potential platform for improved drug delivery. |
| Starting Page | 1124 |
| e-ISSN | 20734360 |
| DOI | 10.3390/polym12051124 |
| Journal | Polymers |
| Issue Number | 5 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-05-14 |
| Access Restriction | Open |
| Subject Keyword | Polymers Biophysics Biomaterials Emulsion Poly(ethylene Glycol) Polymer Capsules Targeting Drug Delivery |
| Content Type | Text |
| Resource Type | Article |
