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Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial
| Content Provider | MDPI |
|---|---|
| Author | So, Winnie Chan, Judy Law, Bernard Choi, Kai Ching, Jessica Chan, Kam Tang, Raymond Chan, Carmen Wu, Justin Tsui, Stephen |
| Copyright Year | 2021 |
| Description | Rice bran exhibits chemopreventive properties that may help to prevent colorectal cancer (CRC), and a short-term rice bran dietary intervention may promote intestinal health via modification of the intestinal microbiota. We conducted a pilot, double-blind, randomised placebo-controlled trial to assess the feasibility of implementing a long-term (24-week) rice bran dietary intervention in Chinese subjects with a high risk of CRC, and to examine its effects on the composition of their intestinal microbiota. Forty subjects were randomised into the intervention group (n = 19) or the control group (n = 20). The intervention participants consumed 30 g of rice bran over 24-h intervals for 24 weeks, whilst the control participants consumed 30 g of rice powder on the same schedule. High rates of retention (97.5%) and compliance (≥91.3%) were observed. No adverse effects were reported. The intervention significantly enhanced the intestinal abundance of Firmicutes and Lactobacillus, and tended to increase the Firmicutes/Bacteroidetes ratio and the intestinal abundance of Prevotella_9 and the health-promoting Lactobacillales and Bifidobacteria, but had no effect on bacterial diversity. Overall, a 24-week rice bran dietary intervention was feasible, and may increase intestinal health by inducing health-promoting modification of the intestinal microbiota. Further larger-scale studies involving a longer intervention duration and multiple follow-up outcome assessments are recommended. |
| Starting Page | 526 |
| e-ISSN | 20726643 |
| DOI | 10.3390/nu13020526 |
| Journal | Nutrients |
| Issue Number | 2 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-02-06 |
| Access Restriction | Open |
| Subject Keyword | Nutrients Integrative and Complementary Medicine Rice Bran Dietary Intervention Intestinal Microbiota Intestinal Health Colorectal Cancer |
| Content Type | Text |
| Resource Type | Article |
