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Effects of Perioperative Oral Nutrition Supplementation in Malaysian Patients Undergoing Elective Surgery for Breast and Colorectal Cancers—A Randomised Controlled Trial
| Content Provider | MDPI |
|---|---|
| Author | Wong, Ting Xuan Wong, Wei Xiang Chen, Seong Ting Ong, Shu Hwa Shyam, Sangeetha Ahmed, Nurzarina Hamdan, Khairul Hazim Awang, Raflis Ruzairee Ibrahim, Mohd Razali Palayan, Kandasami Chee, Winnie Siew Swee |
| Copyright Year | 2022 |
| Description | This study aimed to investigate the effectiveness of preoperative and an extended 90-days postoperative use of ONS among patients undergoing elective surgery for breast and colorectal cancers. Ninety-one patients were randomised into (i) Group SS received ONS up to 14 days preoperatively and postoperatively up to discharge, (ii) Group SS-E received ONS up to 14 days preoperatively, postoperatively up to discharge and for an extended 90-days after discharge and (iii) Group DS received ONS postoperatively up to discharge. Preoperatively, SS had significantly higher body weight (66.1 ± 15.3 kg vs. 62.5 ± 12.0 kg, p = 0.010) and BMI (26.8 ± 6.8 $kg/m^{2}$ vs. 26.1 ± 6.7 $kg/m^{2}$, p = 0.022) than DS when adjusted for baseline values. Postoperatively, SS-E had significantly higher handgrip strength (26 ± 9 kgF vs. 24 ± 6 kgF, p = 0.044) than DS at 90-days post-discharge after adjusted for preoperative values. At 90-days post-discharge, the proportions of patients in SS with albumin < 35 g/d, CAR ≥ 0.1, mPINI ≥ 0.4, mGPS score 1 or 2 were significantly reduced while in SS-E, the reduction in proportions of patients with high hsCRP and mPINI ≥ 0.4 was significant compared to upon discharge. Preoperative ONS had modest benefits in attenuating weight loss whilst postoperative supplementation up to 90-days post-discharge improved handgrip strength and inflammatory prognostic markers. |
| Starting Page | 615 |
| e-ISSN | 20726643 |
| DOI | 10.3390/nu14030615 |
| Journal | Nutrients |
| Issue Number | 3 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-30 |
| Access Restriction | Open |
| Subject Keyword | Nutrients Integrative and Complementary Medicine Perioperative Nutrition Care Breast Cancer Colorectal Cancer Non-severe Malnutrition Surgical Outcomes |
| Content Type | Text |
| Resource Type | Article |
