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Utility of Real-Time Three-Dimensional Echocardiography for the Assessment of Right Ventricular Morphology and Function in Large Animal Models
| Content Provider | MDPI |
|---|---|
| Author | Yuchi, Yunosuke Suzuki, Ryohei Higuchi, Riho Saito, Takahiro Teshima, Takahiro Matsumoto, Hirotaka Koyama, Hidekazu |
| Copyright Year | 2022 |
| Description | Real-time three-dimensional echocardiography (RT3DE) enables a noninvasive assessment of right ventricular (RV) morphology. However, no study has evaluated the relationship between RV function obtained by RT3DE and RV pressure-volume loops. This hypothesis-driven, experimental study aimed to assess the utility of RT3DE in the evaluation of RV morphology and function. Ten anesthetized beagle dogs sequentially underwent dobutamine infusion, acute infusion of lactated Ringer’s solution, and furosemide administration to alter RV contractility and loading conditions. RV pressure-volume loop-derived hemodynamic measurements and echocardiography, including two-dimensional speckle-tracking echocardiography and RT3DE, were performed in each study protocol. Bland–Altman analysis showed strong agreement in RV volume, ejection fraction, and stroke volume obtained by right heart catheterization and RT3DE. Multiple regression analyses revealed that the peak myocardial velocity of the lateral tricuspid annulus (RV s’) and global RV longitudinal strain rate were significantly associated with end-systolic elastance (adjusted $r^{2}$ = 0.66, p < 0.001). RV s’, RV free wall longitudinal strain, and RT3DE-derived stroke volume/end-systolic RV volume ratio were associated with RV pressure-volume loops-derived end-systolic/arterial elastance ratio (adjusted $r^{2}$ = 0.34, p < 0.001). RT3DE could detect the changes in catheterization-derived RV volume with a strong agreement and might be useful in estimating RV-pulmonary arterial coupling. |
| Starting Page | 2001 |
| e-ISSN | 20770383 |
| DOI | 10.3390/jcm11072001 |
| Journal | Journal of clinical medicine |
| Issue Number | 7 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-04-02 |
| Access Restriction | Open |
| Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Peripheral Vascular Disease Canine Coupling Ejection Fraction Pressure-volume Loop Right Heart Catheterization Right Ventricular Volume Right Ventricular Performance Speckle Tracking Echocardiography Strain Stroke Volume |
| Content Type | Text |
| Resource Type | Article |
