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Ratio between Right Ventricular Longitudinal Strain and Pulmonary Arterial Systolic Pressure: Novel Prognostic Parameter in Patients Undergoing Cardiac Resynchronization Therapy
Content Provider | MDPI |
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Author | Deaconu, Silvia Deaconu, Alexandru Scarlatescu, Alina Petre, Ioana Onciul, Sebastian Vijiiac, Aura Zamfir, Diana Marascu, Gabriela Iorgulescu, Corneliu Radu, Andrei Bogdan, Stefan Vatasescu, Radu |
Copyright Year | 2021 |
Description | Background: We aimed to evaluate whether right ventricle (RV) longitudinal strain indexed to pulmonary arterial systolic pressure (PASP) has prognostic significance in patients undergoing cardiac resynchronization therapy (CRT). Methods: Patients undergoing CRT were prospectively included. The primary endpoint was adverse cardiovascular events (death and HF-related hospitalizations). RV global longitudinal strain (RVGLS) and RV free wall strain (RVfwS) were measured by speckle tracking and indexed to echocardiographic estimated PASP. Results: A total of 54 patients (64.0 ± 13.8 years; 58% male) were included. After 33 ± 12.9 months, the primary endpoint occurred in 18 patients. Baseline RVGLS/PASP and RVfwS/PASP showed good discriminative ability for response to CRT (AUC = 0.88, 95% CI (0.74–1) and AUC = 0.87, 95% CI (0.77–1)). RVGLS/PASP and RVfwS/PASP were significantly associated with high risk of events at univariate analysis (HR 0.039, 95% CI (0.001–0.8) p < 0.05, respectively HR = 0.049, 95% CI (0.0033–0.72), p < 0.05). Upon multivariate Cox regression analysis, RVGLS/PASP and RVfwS/PASP remained associated with high risk of events (HR 0.018, 95% CI (0.0005–0.64), p = 0.02 and HR 0.015, 95% CI (0.0004–0.524), p = 0.01) after correction for gender, etiology, QRS duration and morphology. Conclusions: Indexing RV longitudinal strain (global and free wall) by PASP provides a parameter, which independently identifies patients with high risk of cardiovascular events and predicts non-response to CRT. |
Starting Page | 2442 |
e-ISSN | 20770383 |
DOI | 10.3390/jcm10112442 |
Journal | Journal of clinical medicine |
Issue Number | 11 |
Volume Number | 10 |
Language | English |
Publisher | MDPI |
Publisher Date | 2021-05-31 |
Access Restriction | Open |
Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Peripheral Vascular Disease Right Ventricle Strain Speckle Tracking Pulmonary Systolic Arterial Pressure Right Ventricular Function Cardiac Resynchronization Therapy Heart Failure Right Ventricular Arterial Coupling Pulmonary Circulation |
Content Type | Text |
Resource Type | Article |