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Phytochemical Analysis, Pharmacological and Safety Evaluations of Halophytic Plant, Salsola cyclophylla
| Content Provider | MDPI |
|---|---|
| Author | Mohammed, Hamdoon Al-Omar, Mohsen Mohammed, Salman Alhowail, Ahmad Eldeeb, Hussein Sajid, Mohammed Abd-Elmoniem, Essam Alghulayqeh, Osama Kandil, Yasser Khan, Riaz |
| Copyright Year | 2021 |
| Description | Salsola cyclophylla, an edible halophyte, is traditionally used for inflammation and pain. To confirm the claimed anti-inflammatory and analgesic properties, a detailed study on respective pharmacological actions was undertaken. The activities are contemplated to arise from its phytoconstituents. The LC-MS analysis of S. cyclophylla 95% aqueous-ethanolic extract revealed the presence of 52 compounds belonging to phenols, flavonoids, coumarins, and aliphatics class. A high concentration of Mn, Fe, and Zn was detected by atomic absorption spectroscopic analysis. The ethyl acetate extract showed the highest flavonoid contents (5.94 ± 0.04 mg/g, Quercetin Equivalents) and Fe2+-chelation (52%) potential with DPPH radicals-quenching IC50 at 1.35 ± 0.16 mg/mL, while the aqueous ethanolic extract exhibited maximum phenolics contents (136.08 ± 0.12 mg/g, gallic acid equivalents) with DPPH scavenging potential at IC50 0.615 ± 0.06 mg/mL. Aqueous ethanolic extract and standard quercetin DPPH radicals scavenging’s were equal potent at 10 mg/mL concentrations. The aqueous ethanolic extract showed highest analgesic effect with pain reduction rates 89.86% (p = 0.03), 87.50% (p < 0.01), and 99.66% (p = 0.0004) after 60, 90, and 120 min, respectively. Additionally, aqueous ethanolic extract exhibited the highest anti-inflammation capacity at 41.07% (p < 0.0001), 34.51% (p < 0.0001), and 24.82% (p < 0.0001) after 2, 3, and 6 h of extract’s administration, respectively. The phytochemical constituents, significant anti-oxidant potential, remarkable analgesic, and anti-inflammatory bioactivities of extracts supported the traditionally claimed anti-inflammatory and analgesic plant activities. |
| Starting Page | 2384 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules26082384 |
| Journal | Molecules |
| Issue Number | 8 |
| Volume Number | 26 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-04-20 |
| Access Restriction | Open |
| Subject Keyword | Molecules Integrative and Complementary Medicine Salsola Cyclophylla Halophyte Trace Elements Lc-ms Anti-oxidant Anti-inflammatory Analgesic Activity Cytotoxicity Toxicity Evaluation |
| Content Type | Text |
| Resource Type | Article |
