NDLI: Metabolic Control of $m^{6}$A RNA Modification

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Metabolic Control of $m^{6}$A RNA Modification

Content Provider	MDPI
Author	Kim, Joohwan Lee, Gina
Copyright Year	2021
Description	Nutrients and metabolic pathways regulate cell growth and cell fate decisions via epigenetic modification of DNA and histones. Another key genetic material, RNA, also contains diverse chemical modifications. Among these, N 6-methyladenosine (m6A) is the most prevalent and evolutionarily conserved RNA modification. It functions in various aspects of developmental and disease states, by controlling RNA metabolism, such as stability and translation. Similar to other epigenetic processes, m6A modification is regulated by specific enzymes, including writers (methyltransferases), erasers (demethylases), and readers (m6A-binding proteins). As this is a reversible enzymatic process, metabolites can directly influence the flux of this reaction by serving as substrates and/or allosteric regulators. In this review, we will discuss recent understanding of the regulation of m6A RNA modification by metabolites, nutrients, and cellular metabolic pathways.
Starting Page	80
e-ISSN	22181989
DOI	10.3390/metabo11020080
Journal	Metabolites
Issue Number	2
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2021-01-30
Access Restriction	Open
Subject Keyword	Metabolites Cell Biology N6-methyladenosine M6a Rna Methylation Rna Chemical Modification Rna Epitranscriptome Nutrient Signaling Metabolic Pathways
Content Type	Text
Resource Type	Article

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