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Nanoparticle-Induced $m^{6}$A RNA Modification: Detection Methods, Mechanisms and Applications
| Content Provider | MDPI |
|---|---|
| Author | Wang, Yi Ruan, Fengkai Zuo, Zhenghong He, Chengyong |
| Copyright Year | 2022 |
| Description | With the increasing application of nanoparticles (NPs) in medical and consumer applications, it is necessary to ensure their safety. As $m^{6}$A $(N^{6}$-methyladenosine) RNA modification is one of the most prevalent RNA modifications involved in many diseases and essential biological processes, the relationship between nanoparticles and $m^{6}$A RNA modification for the modulation of these events has attracted substantial research interest. However, there is limited knowledge regarding the relationship between nanoparticles and $m^{6}$A RNA modification, but evidence is beginning to emerge. Therefore, a summary of these aspects from current research on nanoparticle-induced $m^{6}$A RNA modification is timely and significant. In this review, we highlight the roles of $m^{6}$A RNA modification in the bioimpacts of nanoparticles and thus elaborate on the mechanisms of nanoparticle-induced $m^{6}$A RNA modification. We also summarize the dynamic regulation and biofunctions of $m^{6}$A RNA modification. Moreover, we emphasize recent advances in the application perspective of nanoparticle-induced $m^{6}$A RNA modification in medication and toxicity of nanoparticles to provide a potential method to facilitate the design of nanoparticles by deliberately tuning $m^{6}$A RNA modification. |
| Starting Page | 389 |
| e-ISSN | 20794991 |
| DOI | 10.3390/nano12030389 |
| Journal | Nanomaterials |
| Issue Number | 3 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-25 |
| Access Restriction | Open |
| Subject Keyword | Nanomaterials Nanosafety (n6-methyladenosine) Rna Modification Function of M6a Epigenetics |
| Content Type | Text |
| Resource Type | Article |
