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Antioxidant and Enzyme Inhibitory Properties, and HPLC–MS/MS Profiles of Different Extracts of Arabis carduchorum Boiss.: An Endemic Plant to Turkey
| Content Provider | MDPI |
|---|---|
| Author | Uba, Abdullahi Ibrahim Zengin, Gokhan Montesano, Domenico Cakilcioglu, Ugur Selvi, Selami Ulusan, Musa Denizhan Caprioli, Giovanni Sagratini, Gianni Angeloni, Simone Jugreet, Sharmeen Hasan, Mohammad Mehedi Mahoomodally, Mohamad Fawzi |
| Copyright Year | 2022 |
| Description | In this study, six extracts of Arabis carduchorum prepared from solvents of varying polarity (water, methanol, ethyl acetate, dichloromethane, and n-hexane) were investigated for their chemical profiles and total phenolic and flavonoid contents (TPC/TFC) using HPLC–MS/MS and spectrophotometric/colorimetric assays, respectively, along with the assessment of their antioxidant and enzyme inhibitory effects. In general, the polar extracts (methanol, water, and infusion) showed higher TPC/TFC than the other extracts (range: 13.73–26.62 mg GAE/g; 2.66–52.95 mg RE/g, respectively). The total antioxidant capacity of the polar extracts ranged from 0.90–1.85 mmol TE/g in phosphomolybdenum assay, while the free radical scavenging potential ranged from 4.36–32.13 mg TE/g and 12.58–67.73 mg TE/g in DPPH and ABTS assays, respectively. While the water and infuse extract inhibited only butyrylcholinesterase (2.68 and 2.39 mg GALAE/g, respectively), the other extracts were found to inhibit both acetyl- and butyryl-cholinesterases (0.96–2.73 mg GALAE/g and 1.86–5.11 mg GALAE/g, respectively). On the contrary, all extracts exhibited anti-tyrosinase (40.24–59.22 mg KAE/g) and anti-amylase (0.09–0.63 mmol ACAE/g) activities. Overall, this study highlighted the effect of solvent polarity on the extraction of bioactive compounds and the biological properties of the extracts of A. carduchorum; hence, the results obtained could be used to guide optimum extraction in future studies. |
| Starting Page | 6561 |
| e-ISSN | 20763417 |
| DOI | 10.3390/app12136561 |
| Journal | Applied Sciences |
| Issue Number | 13 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-06-28 |
| Access Restriction | Open |
| Subject Keyword | Applied Sciences Integrative and Complementary Medicine Arabis Carduchorum Phenolics Flavonoids Hplc–ms/ms Solvent Polarity Antioxidant Enzyme Inhibition |
| Content Type | Text |
| Resource Type | Article |
