Loading...
Please wait, while we are loading the content...
Similar Documents
Mucosal Vaccines, Sterilizing Immunity, and the Future of SARS-CoV-2 Virulence
| Content Provider | MDPI |
|---|---|
| Author | Focosi, Daniele Maggi, Fabrizio Casadevall, Arturo |
| Copyright Year | 2022 |
| Description | Sterilizing immunity after vaccination is desirable to prevent the spread of infection from vaccinees, which can be especially dangerous in hospital settings while managing frail patients. Sterilizing immunity requires neutralizing antibodies at the site of infection, which for respiratory viruses such as SARS-CoV-2 implies the occurrence of neutralizing IgA in mucosal secretions. Systemic vaccination by intramuscular delivery induces no or low-titer neutralizing IgA against vaccine antigens. Mucosal priming or boosting, is needed to provide sterilizing immunity. On the other side of the coin, sterilizing immunity, by zeroing interhuman transmission, could confine SARS-CoV-2 in animal reservoirs, preventing spontaneous attenuation of virulence in humans as presumably happened with the endemic coronaviruses. We review here the pros and cons of each vaccination strategy, the current mucosal SARS-CoV-2 vaccines under development, and their implications for public health. |
| Starting Page | 187 |
| e-ISSN | 19994915 |
| DOI | 10.3390/v14020187 |
| Journal | Viruses |
| Issue Number | 2 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-19 |
| Access Restriction | Open |
| Subject Keyword | Viruses Virology Covid-19 Sars-cov-2 Neutralizing Antibody Bnt162b2 Mrna-1273 Iga Igg Sterilizing Immunity Mucosal Vaccines Intranasal Vaccine Oral Vaccines |
| Content Type | Text |
| Resource Type | Article |
