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Anti-Inflammatory and Antinociceptive Activities of the Essential Oil of Tagetes parryi A. Gray (Asteraceae) and Verbenone
| Content Provider | MDPI |
|---|---|
| Author | Hansel, E. González-Velasco Mar, ía S. Pérez-Gutiérrez Perla, del C. Niño-Moreno Marco, M. González-Chávez Alonso-Castro, Ángel J. Zapata-Morales, Juan R. Campos-Xolalpa, Nimsi |
| Copyright Year | 2022 |
| Description | Tagetes parryi is a plant empirically used to treat gastrointestinal and inflammatory diseases, its essential oil (EOTP) was obtained from the aerial parts, and the composition was elucidated by GC-MS. The in vivo and in vitro anti-inflammatory activities and the antinociceptive activity of EOTP and (1S)-(-)-verbenone (VERB) were assessed. The major compounds identified for EOTP were verbenone (33.39%), dihydrotagetone (26.88%), and tagetone (20.8%). EOTP and VERB diminished the ear oedema induced with TPA by 93.77 % and 81.13 %, respectively. EOTP and VERB decreased inflammation in a 12-O-tetradecanoylphorbol-13-acetate (TPA) chronic model with $ED_{50}$ = 54.95 mg/kg and 45.24 mg/kg, respectively. EOTP (15 µg/mL) inhibited the in vitro production of the pro-inflammatory mediators NO (67.02%), TNF-α (69.21%), and IL-6 (58.44%) in LPS-stimulated macrophages. In the acetic induced writhing test, EOTP and VERB showed antinociceptive effects with $ED_{50}$ = 84.93 mg/kg and $ED_{50}$ = 45.24 mg/kg, respectively. In phase 1 of the formalin test, EOTP and VERB showed no antinociceptive effects, whereas in phase 2, EOTP $(ED_{50}$ = 35.45 mg/kg) and VERB $(ED_{50}$ = 24.84 mg/kg) showed antinociceptive effects. The antinociceptive actions of ETOP and VERB were blocked with the co-administration of L-NAME. This study suggests that EOTP and VERB might be used in the treatment of pain and inflammatory problems. |
| Starting Page | 2612 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules27092612 |
| Journal | Molecules |
| Issue Number | 9 |
| Volume Number | 27 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-04-19 |
| Access Restriction | Open |
| Subject Keyword | Molecules Integrative and Complementary Medicine Tagetes Parryi Essential Oil Verbenone Anti-inflammation Antinociceptive |
| Content Type | Text |
| Resource Type | Article |
