NDLI: Untargeted Metabolomics for the Diagnosis of Exocrine Pancreatic Insufficiency in Chronic Pancreatitis

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Untargeted Metabolomics for the Diagnosis of Exocrine Pancreatic Insufficiency in Chronic Pancreatitis

Content Provider	MDPI
Author	Caridad, Díaz Cristina, Jiménez-Luna Carmelo, Diéguez-Castillo Ariadna, Martín Jos, é Luis Martín-Ruíz Prados, José Genilloud, Olga Vicente, Francisca Palacio, José Pérez del Caba, Octavio
Copyright Year	2021
Description	Background and Objectives: The clinical manifestations and course of chronic pancreatitis (CP) are often nonspecific and variable, hampering diagnosis of the risk of exocrine pancreatic insufficiency (EPI). Development of new, reproducible, and non-invasive methods to diagnose EPI is therefore a major priority. The objective of this metabolomic study was to identify novel biomarkers associated with EPI. Materials and Methods: We analyzed 53 samples from patients with CP, 32 with and 21 without EPI, using an untargeted metabolomics workflow based on hydrophilic interaction chromatography coupled to high-resolution mass spectrometry. Principal component and partial least squares-discriminant analyses showed significant between-group differentiation, and univariate and multivariate analyses identified potential candidate metabolites that significantly differed between samples from CP patients with EPI and those without EPI. Results: Excellent results were obtained using a six-metabolic panel to diagnose the presence of EPI in CP patients (area under the ROC curve = 0.785). Conclusions: This study confirms the usefulness of metabolomics in this disease setting, allowing the identification of novel biomarkers to differentiate between the presence and absence of EPI in CP patients.
Starting Page	876
e-ISSN	16489144
DOI	10.3390/medicina57090876
Journal	Medicina
Issue Number	9
Volume Number	57
Language	English
Publisher	MDPI
Publisher Date	2021-08-26
Access Restriction	Open
Subject Keyword	Medicina Gastroenterology and Hepatology Metabolomics Exocrine Pancreatic Insufficiency Chronic Pancreatitis Biomarker Diagnosis High-resolution Mass Spectrometry
Content Type	Text
Resource Type	Article

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