Total cholesterol level for assessing pancreatic insufficiency due to chronic pancreatitis.

Content Provider	Europe PMC
Author	Hirano, Kenji Saito, Tomotaka Mizuno, Suguru Tada, Minoru Sasahira, Naoki Isayama, Hiroyuki Matsukawa, Miho Umefune, Gyotane Akiyama, Dai Saito, Kei Kawahata, Shuhei Takahara, Naminatsu Uchino, Rie Hamada, Tsuyoshi Miyabayashi, Koji Mohri, Dai Sasaki, Takashi Kogure, Hirofumi Yamamoto, Natsuyo Nakai, Yosuke Koike, Kazuhiko
Copyright Year	2014
Abstract	Background/AimsTo determine the nutritional markers important for assessing the degree of pancreatic insufficiency due to chronic pancreatitis in routine clinical practice.MethodsA total of 137 patients with chronic pancreatitis were followed up for more than 1 year. They were divided into two groups: a pancreatic diabetes mellitus (DM) group, consisting of 47 patients undergoing medical treatment for DM of pancreatic origin, and a nonpancreatic DM group, consisting of 90 other patients (including 86 patients without DM). Serum albumin, prealbumin, total cholesterol, cholinesterase, magnesium, and hemoglobin were compared between the two groups.ResultsThe total cholesterol was significantly lower in the pancreatic than the nonpancreatic DM group (164 mg/dL vs 183 mg/dL, respectively; p=0.0028). Cholinesterase was significantly lower in the former group (263 U/L vs 291 U/L, respectively; p=0.016). Among the 37 patients with nonalcoholic pancreatitis, there was no difference in the cholinesterase levels between the pancreatic and nonpancreatic (296 U/L vs 304 U/L, respectively; p=0.752) DM groups, although cholesterol levels remained lower in the former (165 mg/dL vs 187 mg/dL, respectively; p=0.052).ConclusionsCholinesterase levels are possibly affected by concomitant alcoholic liver injury. The total cholesterol level should be considered when assessing pancreatic insufficiency due to chronic pancreatitis.
ISSN	19762283
Journal	Gut and Liver
Volume Number	8
PubMed Central reference number	PMC4164258
Issue Number	5
PubMed reference number	25228979
e-ISSN	20051212
DOI	10.5009/gnl13366
Language	English
Publisher	Gut and Liver
Publisher Date	2014-04-23
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2014 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer.
Subject Keyword	Chronic pancreatitis Pancreatic exocrine insufficiency Diabetes mellitus Cholesterol Cholinesterase
Content Type	Text
Resource Type	Article
Subject	Hepatology Gastroenterology