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Testosterone as a Biomarker of Adverse Clinical Outcomes in SARS-CoV-2 Pneumonia
| Content Provider | MDPI |
|---|---|
| Author | Marinelli, Lorenzo Beccuti, Guglielmo Zavattaro, Marco Cagnina, Serena Gesmundo, Iacopo Bona, Chiara Lopez, Chiara Scabini, Silvia Canta, Francesca Pinna, Simone Mornese Lupia, Tommaso Bisceglie, Cataldo Di Ponzetto, Federico Settanni, Fabio Rosa, Francesco Giuseppe De Ghigo, Ezio Motta, Giovanna |
| Copyright Year | 2022 |
| Description | Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect testicles. Lower testosterone levels have been associated with worse clinical outcomes and higher mortality. Our objective was to evaluate the hypothalamic–pituitary–gonadal axis of men admitted with SARS-CoV-2 pneumonia and its link with the pneumonia-treatment intensification. Short-term changes in hormonal parameters were also assessed. Methods: Men admitted with SARS-CoV-2 pneumonia were recruited in two different hospitals in Piedmont, Italy. In all patients, the assessment of total testosterone (TT), calculated free testosterone (cFT), gonadotropins, inhibin B (InhB), and other biochemical evaluations were performed at admission (T0) and before discharge (T1). Through a review of medical records, clinical history was recorded, including data on pneumonia severity. Results: Thirty-five men (median age 64 [58–74] years) were recruited. Lower TT and cFT levels at T0 were associated with CPAP therapy (p = 0.045 and 0.028, respectively), even after adjusting for age and $PaO_{2}/FIO_{2}$ ratio in a multivariable analysis. In those discharged alive, lower TT and cFT levels were associated with longer hospital stay (p < 0.01). TT, cFT, and InhB were below the normal range at T0 and significantly increased at T1 (TT 1.98 [1.30–2.72] vs. 2.53 [1.28–3.37] ng/mL, p = 0.038; cFT (0.0441 [0.0256–0.0742] vs. 0.0702 [0.0314–0.0778] ng/mL, p = 0.046; InhB 60.75 [25.35–88.02] vs. 77.05 [51.15–134.50], p < 0.01). Conclusions: Both TT and cFT levels are associated with adverse clinical outcomes in men admitted with SARS-CoV-2 pneumonia. As TT, cFT and InhB levels increase before discharge, short-term functional recovery of steroidogenesis and an indirect improvement of spermatozoa functional status could be hypothesized. |
| Starting Page | 820 |
| e-ISSN | 22279059 |
| DOI | 10.3390/biomedicines10040820 |
| Journal | Biomedicines |
| Issue Number | 4 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-03-31 |
| Access Restriction | Open |
| Subject Keyword | Biomedicines Womens Studies Sars-cov-2 Covid-19 Pneumonia Testosterone Men Hypogonadism Hospitalization Mortality Fertility |
| Content Type | Text |
| Resource Type | Article |
