NDLI: Circulating Calprotectin as a Predictive and Severity Biomarker in Patients with COVID-19

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Circulating Calprotectin as a Predictive and Severity Biomarker in Patients with COVID-19

Content Provider	MDPI
Author	Norman, Gary L. Navaz, Sherwin A. Kanthi, Yogendra Albesa, Roger Mahler, Michael Knight, Jason S. Zuo, Yu
Copyright Year	2022
Description	Background: New tools for the assessment and prediction of the severity of hospitalized COVID-19 patients can help direct limited resources to patients with the greatest need. Circulating levels of calprotectin (S100A8/S100A9) reflect inflammatory activity in multiple conditions, and have been described as being elevated in COVID-19 patients, but their measurement is not routinely utilized. The aim of our study was to assess the practical and predictive value of measuring circulating calprotectin levels in patients at admission and during their hospitalization. Methods: Circulating calprotectin levels were measured in 157 hospitalized patients with COVID-19 using an automated quantitative chemiluminescent assay. Results: Circulating calprotectin levels were strongly correlated with changing respiratory supplementation needs of patients. The overall trajectory of circulating calprotectin levels generally correlated with patient improvement or deterioration. Conclusions: Routine measurement of circulating calprotectin levels may offer a valuable tool to assess and monitor hospitalized patients with COVID-19, as well as other acute inflammatory conditions.
Starting Page	1324
e-ISSN	20754418
DOI	10.3390/diagnostics12061324
Journal	Diagnostics
Issue Number	6
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2022-05-27
Access Restriction	Open
Subject Keyword	Diagnostics Womens Studies Calprotectin Serum Biomarker Covid-19 Sars-cov-2 Severity Predictive Chemiluminescent Immunoassay S100a8/s100a9
Content Type	Text
Resource Type	Article

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