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The Inhibitory Effects of New Zealand Pine Bark $(Enzogenol^{®}$) on α-Amylase, α-Glucosidase, and Dipeptidyl Peptidase-4 (DPP-4) Enzymes
| Content Provider | MDPI |
|---|---|
| Author | Lim, Wen Xin Janice Gammon, Cheryl S. von Hurst, Pamela Chepulis, Lynne Page, Rachel A. |
| Copyright Year | 2022 |
| Description | The New Zealand pine bark extract $(Enzogenol^{®}$) has previously been shown to elicit acute hypoglycaemic effects in humans. The present study investigated the underlying mechanisms of $Enzogenol^{®}$ in reducing postprandial glucose in humans. The potential inhibitory action of $Enzogenol^{®}$ against digestive enzymes: α-amylase and α-glucosidase, and dipeptidyl peptidase-4 (DPP-4) enzyme was determined. $Enzogenol^{®}$ demonstrated the ability to inhibit all three enzymes: α-amylase enzyme activity $(IC_{50}$ 3.98 ± 0.11 mg/mL), α-glucosidase enzyme activity $(IC_{50}$ 13.02 ± 0.28 μg/mL), and DPP-4 enzyme activity $(IC_{50}$ 2.51 ± 0.04 mg/mL). The present findings indicate the potential for $Enzogenol^{®}$ to improve postprandial glycaemia by delaying carbohydrate digestion via the inhibition of digestive enzymes (α-amylase and α-glucosidase), and enhancing the incretin effect via inhibiting the dipeptidyl-peptidase-4 enzyme. The inhibitory actions of $Enzogenol^{®}$ on enzymes should therefore be further validated in humans for its potential use in type 2 diabetes mellitus prevention and management. |
| Starting Page | 1596 |
| e-ISSN | 20726643 |
| DOI | 10.3390/nu14081596 |
| Journal | Nutrients |
| Issue Number | 8 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-04-12 |
| Access Restriction | Open |
| Subject Keyword | Nutrients Integrative and Complementary Medicine Functional Food Hyperglycaemia Hypoglycaemic Effects Impaired Glycaemic Control Incretin Effect Polyphenol Starch Inhibition |
| Content Type | Text |
| Resource Type | Article |
