NDLI: Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes

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Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes

Content Provider	MDPI
Author	Singh, Anand-Krishna Yadav, Dhananjay Sharma, Neha Jin, Jun-O
Copyright Year	2021
Description	Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that is predominantly caused by insulin resistance or impaired insulin secretion, along with disturbances in carbohydrate, fat and protein metabolism. Various therapeutic approaches have been used to treat diabetes, including improvement of insulin sensitivity, inhibition of gluconeogenesis, and decreasing glucose absorption from the intestines. Recently, a novel approach has emerged using dipeptidyl peptidase-IV (DPP-IV) inhibitors as a possible agent for the treatment of T2DM without producing any side effects, such as hypoglycemia and exhaustion of pancreatic β-cells. DPP-IV inhibitors improve hyperglycemic conditions by stabilizing the postprandial level of gut hormones such as glucagon-like peptide-1, and glucose-dependent insulinotropic polypeptides, which function as incretins to help upregulate insulin secretion and β-cell mass. In this review, we summarized DPP-IV inhibitors and their mechanism of inhibition, activities of those isolated from various natural sources, and their capacity to overcome oxidative stress in disease conditions.
Starting Page	586
e-ISSN	14248247
DOI	10.3390/ph14060586
Journal	Pharmaceuticals
Issue Number	6
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2021-06-18
Access Restriction	Open
Subject Keyword	Pharmaceuticals Integrative and Complementary Medicine Dipeptidyl Peptidase-iv Glucagon-like Peptide-1 Hyperglycemia Incretin Antioxidant
Content Type	Text
Resource Type	Article

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