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Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation
| Content Provider | MDPI |
|---|---|
| Author | Memon, Azra Kim, Bae Kim, Se-Eun Pyao, Yuliya Lee, Yeong-Geun Kang, Se Lee, Woon |
| Copyright Year | 2021 |
| Description | Background: Phytoncide is known to have antimicrobial and anti-inflammatory properties. Purpose: This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. Methods: We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. Result: In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited (p < 0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group (p < 0.05). Conclusions: Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent. |
| Starting Page | 1895 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules26071895 |
| Journal | Molecules |
| Issue Number | 7 |
| Volume Number | 26 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-26 |
| Access Restriction | Open |
| Subject Keyword | Molecules Integrative and Complementary Medicine Pinus Koraiensis Phytoncide Anti-inflammation Gastritis Colitis |
| Content Type | Text |
| Resource Type | Article |
