NDLI: Hepatoprotective Effects of Pleurotus ostreatus Protein Hydrolysates Yielded by Pepsin Hydrolysis

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Hepatoprotective Effects of Pleurotus ostreatus Protein Hydrolysates Yielded by Pepsin Hydrolysis

Content Provider	MDPI
Author	Zhang, Liwei Lu, Yuxiao Feng, Xiaobin Liu, Qinghong Li, Yuanhui Hao, Jiamin Wang, Yanqiong Dong, Yongqiang Wang, Huimin David
Copyright Year	2020
Description	Pleurotus ostreatus protein extract (POPE) was prepared by the alkali precipitation method with 0.3% (w/v) NaOH. POPEP-III with a MW of 3000–5000 Da was acquired by pepsin enenzymatic hydrolysis. POPEP-III displayed noteworthy effects of 1,1-diphenyl-2-picrylhydrazyl DPPH and H2O2 scavenging activities, Fe2+ chelating ability, lipid peroxidation inhibition capacity, and metal reducing power. The administration of POPEP-III in mice significantly prevented prior CCl4-induced strengthen serum ALT and AST activities, changing from 365.44 ± 36.87 IU/L to 220.23 ± 22.27 IU/L and 352.52 IU/L to 206.75 ± 17.26 IU/L, respectively (p < 0.001), and suppressed hepatic malondialdehyde (MDA) formation from 15.28 ± 3.47 nmol/mg prot to 10.04 ± 2.06 nmol/mg prot (p < 0.001). Mice treated with POPEP-III demonstrated augmented activities of superoxide dismutase (SOD) in the liver, from 187.49 ± 19.81 U/mg prot to 233.35 ± 34.23 U/mg prot, and of glutathione peroxidase (GSH-Px), from 84.01 ± 14.54 U/mg prot to 115.9 ± 16.57 U/mg prot (p < 0.05). POPEP-III also prevented CCl4-induced oxidative liver histological alteration. The results suggest that POPEP-III can protect the liver from CCl4-induced oxidative damage.
Starting Page	595
e-ISSN	20734344
DOI	10.3390/catal10060595
Journal	Catalysts
Issue Number	6
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2020-05-26
Access Restriction	Open
Subject Keyword	Catalysts Integrative and Complementary Medicine Pleurotus Ostreatus Enenzymatic Hydrolysis Peptide Antioxidant Hepatoprotective Activity
Content Type	Text
Resource Type	Article

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