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| Content Provider | MDPI |
|---|---|
| Author | Jung, Suk Shin, Jong Pi, Kilwha Goo, Yong Cho, Dong-il |
| Abstract | This paper proposes a neural stimulation device integrated with a silicon nanowire (SiNW)-based photodetection circuit for the activation of neurons with light. The proposed device is comprised of a voltage divider and a current driver in which SiNWs are used as photodetector and field-effect transistors; it has the functions of detecting light, generating a stimulation signal in proportion to the light intensity, and transmitting the signal to a micro electrode. To show the applicability of the proposed neural stimulation device as a high-resolution retinal prosthesis system, a high-density neural stimulation device with a unit cell size of 110 × 110 μ m and a resolution of 32 × 32 was fabricated on a flexible film with a thickness of approximately 50 μm. Its effectiveness as a retinal stimulation device was then evaluated using a unit cell in an in vitro animal experiment involving the retinal tissue of retinal Degeneration 1 (rd1) mice. Experiments wherein stimulation pulses were applied to the retinal tissues successfully demonstrate that the number of spikes in neural response signals increases in proportion to light intensity. |
| File Size | 9660416 |
| File Format | |
| e-ISSN | 14248220 |
| DOI | 10.3390/s16122035 |
| Journal | Sensors |
| Issue Number | 12 |
| Volume Number | 16 |
| Language | English |
| Publisher Date | 2016-12-01 |
| Access Restriction | Open |
| Subject Keyword | neuron stimulation silicon nanowire photodetector micro electrode retinal prosthesis |
| Content Type | Text |
| Resource Type | Article |
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