NDLI: Inherited Variants in Wnt Pathway Genes Influence Outcomes of Prostate Cancer Patients Receiving Androgen Deprivation Therapy

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Inherited Variants in Wnt Pathway Genes Influence Outcomes of Prostate Cancer Patients Receiving Androgen Deprivation Therapy

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Inherited Variants in Wnt Pathway Genes Influence Outcomes of Prostate Cancer Patients Receiving Androgen Deprivation Therapy

Content Provider	MDPI
Author	Geng, Jiun-Hung Lin, Victor Yu, Chia-Cheng Huang, Chao-Yuan Yin, Hsin-Ling Chang, Ta-Yuan Lu, Te-Ling Huang, Shu-Pin Bao, Bo-Ying
Abstract	Aberrant Wnt signaling has been associated with many types of cancer. However, the association of inherited Wnt pathway variants with clinical outcomes in prostate cancer patients receiving androgen deprivation therapy (ADT) has not been determined. Here, we comprehensively studied the contribution of common single nucleotide polymorphisms (SNPs) in Wnt pathway genes to the clinical outcomes of 465 advanced prostate cancer patients treated with ADT. Two SNPs, adenomatous polyposis coli (APC) rs2707765 and rs497844, were significantly (p ≤ 0.009 and q ≤ 0.043) associated with both prostate cancer progression and all-cause mortality, even after multivariate analyses and multiple testing correction. Patients with a greater number of favorable alleles had a longer time to disease progression and better overall survival during ADT (p for trend ≤ 0.003). Additional, cDNA array and in silico analyses of prostate cancer tissue suggested that rs2707765 affects APC expression, which in turn is correlated with tumor aggressiveness and patient prognosis. This study identifies the influence of inherited variants in the Wnt pathway on the efficacy of ADT and highlights a preclinical rationale for using APC as a prognostic marker in advanced prostate cancer.
File Size	1315840
File Format	PDF
e-ISSN	14220067
DOI	10.3390/ijms17121970
Journal	International Journal of Molecular Sciences
Issue Number	12
Volume Number	17
Language	English
Publisher Date	2016-11-26
Access Restriction	Open
Subject Keyword	prostate cancer androgen deprivation therapy outcomes genetic variation Wnt pathway
Content Type	Text
Resource Type	Article

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