NDLI: Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens

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Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens

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Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens

Content Provider	MDPI
Author	Soliman, Sameh Alsaadi, Abrar Youssef, Eman Khitrov, Gregory Noreddin, Ayman Husseiny, Mohamed Ibrahim, Ashraf
Abstract	The fast development of multi-drug resistant (MDR) organisms increasingly threatens global health and well-being. Plant natural products have been known for centuries as alternative medicines that can possess pharmacological characteristics, including antimicrobial activities. The antimicrobial activities of essential oil (Calli oil) extracted from the Calligonum comosum plant by hydro-steam distillation was tested either alone or when combined with lawsone, a henna plant naphthoquinone, against MDR microbes. Lawsone showed significant antimicrobial activities against MDR pathogens in the range of 200–300 µg/mL. Furthermore, Calli oil showed significant antimicrobial activities against MDR bacteria in the range of 180–200 µg/mL, Candida at 220–240 µg/mL and spore-forming Rhizopus fungus at 250 µg/mL. Calli oil’s inhibition effect on Rhizopus, the major cause of the lethal infection mucormycosis, stands for 72 h, followed by an extended irreversible white sporulation effect. The combination of Calli oil with lawsone enhanced the antimicrobial activities of each individual alone by at least three-fold, while incorporation of both natural products in a liposome reduced their toxicity by four- to eight-fold, while maintaining the augmented efficacy of the combination treatment. We map the antimicrobial activity of Calli oil to its major component, a benzaldehyde derivative. The findings from this study demonstrate that formulations containing essential oils have the potential in the future to overcome antimicrobial resistance.
File Size	3392512
File Format	PDF
e-ISSN	14203049
DOI	10.3390/molecules22122223
Journal	Molecules
Issue Number	12
Volume Number	22
Language	English
Publisher Date	2017-12-20
Access Restriction	Open
Subject Keyword	antimicrobials Calligonum essential oil lawsone combination treatment liposomes
Content Type	Text
Resource Type	Article

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8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in