NDLI: In vitro Antioxidant, Antibacterial Activity of C. aromaticus Essential Oil against Multidrug Resistant (MDR) Urinary Tract Infected Pathogens

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In vitro Antioxidant, Antibacterial Activity of C. aromaticus Essential Oil against Multidrug Resistant (MDR) Urinary Tract Infected Pathogens

Content Provider	Semantic Scholar
Author	Subramaniyan, Govindaraju Padikasan, Indra Arulselvi
Copyright Year	2014
Abstract	The present work is aimed to the extraction of essential oil from Coleus aromaticus and evaluation of its antioxidant and antibacterial activity against multidrug resistant urinary tract infected pathogens. Essential oil extracted by steam distillation using Clevenger type apparatus and thus free radical scavenging ability tested with 1,1-Diphenyl-2picrylhydrazyl (DPPH) and Nitric oxide (NO). The antibacterial activities were conducted against urinary tract infected multi drug resistant (MDR) Gram positive (Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis) and Gram negative pathogens (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus vulgaris) by agar diffusion, growth inhibition analysis through optical density measurement. The free radical scavenging ability of essential oil expressed in IC50 (50% of inhibition) value in this for DPPH the IC50 was 54.23μl/ml, whereas nitric oxide scavenging was 72. 91μl/ml. The antibacterial activity of C. aromaticus essential oil is dosage dependent from lower to higher (20-80μl/ml) concentration. Whereas the maximum zone of inhibition was determined in Gram positive pathogens than Gram negative at the higher concentration of 80μl/ml. The highest percentage of growth inhibition was measured in 24hr incubated culture through optical density measurement study. C.aromaticus essential oil possessed potent antioxidant and antibacterial activity and this in vitro study supports its traditional approach as a preventive therapy for the treatment of microbial diseases and replacement of artificial antioxidants.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://impactfactor.org/PDF/IJPPR/6/IJPPR,Vol6,Issue4,Article56.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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