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| Content Provider | MDPI |
|---|---|
| Author | Amri, Bédis Martino, Emanuela Vitulo, Francesca Corana, Federica Kaâb, Leila Bettaieb-Ben Rui, Marta Rossi, Daniela Mori, Michela Rossi, Silvia Collina, Simona |
| Abstract | Several factors contribute in wound generation, e.g., accidental traumas or surgery, and in certain cases, this dermal injury may have a devastating outcome. When skin damage occurs, the human body puts in place a sophisticated choreography, which involves numerous repairing processes to restore physiological conditions. Nevertheless, natural healing mechanisms are ineffective towards chronic or non-healing wounds and thus, therapeutic strategies may represent the only beneficial alternative to counteract these tissue insults. Over the years, numerous studies showed the great potential of plants in promoting wound healing, by virtue of their high contents in antioxidant species. These compounds trigger a molecular cascade that collimate into the promotion of reparative processes. In this article, we report on the potential effect on wound healing of Marrubium vulgare L., a medicinal plant well known for several pharmaceutical activities. To this aim, the methanolic extract was prepared and subjected to a phytochemical investigation, quantifying the amount of marrubiin via NMR and drawing the phytochemical fingerprint via high performance liquid chromatography—ultra violet/photodiode-array detection-electrospray/mass (HPLC-UV/PAD-ESI/MS) analysis. Lastly, the antioxidant properties and wound healing potential have been evaluated. |
| File Size | 3687424 |
| File Format | |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules22111851 |
| Journal | Molecules |
| Issue Number | 11 |
| Volume Number | 22 |
| Language | English |
| Publisher Date | 2017-10-28 |
| Access Restriction | Open |
| Subject Keyword | Wound healing Marrubium vulgare L. leave extract q-NMR antioxidant properties HPLC-UV/PAD MS analysis |
| Content Type | Text |
| Resource Type | Article |
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