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| Content Provider | MDPI |
|---|---|
| Author | Drag, Marcin Surowiak, Pawel Drag-Zalesinska, Malgorzata Dietel, Manfred Lage, Hermann Oleksyszyn, Józef |
| Abstract | Betulin and betulinic acid are naturally occurring pentacyclic triterpenes showing cytotoxicity towards a number of cancer cell lines. These compounds can be found in the bark of the many plants. In this report we have compared the cytotoxic activity of crude birch bark extract and purified betulin and betulinic acid towards human gastric carcinoma (EPG85-257) and human pancreatic carcinoma (EPP85-181) drug-sensitive and drug-resistant (daunorubicin and mitoxantrone) cell lines. Our results show significant differences in sensitivity between cell lines depending on the compound used, and suggest that both betulin and betulinic acid can be considered as a promising leads in the treatment of cancer. |
| File Size | 268288 |
| Ending Page | 1651 |
| Page Count | 13 |
| Starting Page | 1639 |
| File Format | |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules14041639 |
| Journal | Molecules |
| Issue Number | 4 |
| Volume Number | 14 |
| Language | English |
| Publisher Date | 2009-04-24 |
| Access Restriction | Open |
| Subject Keyword | Betulin Betulinic acid Birch Gastric carcinoma Pancreatic carcinoma |
| Content Type | Text |
| Resource Type | Article |
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