NDLI: Identification of Gene Diversity of Melanocortin-4 Receptor and its Relationship with the Birth and Body Size of Beef Cattle

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Identification of Gene Diversity of Melanocortin-4 Receptor and its Relationship with the Birth and Body Size of Beef Cattle

Content Provider	Knowledge E
Author	Albakri, Mw Anugratama, Le Panjono Hartatik, T.
Abstract	Melanocortin-4 Receptor (MC4R) expressed in hypothalamus which is part of the brain that are involved in regulation of appetite, metabolism and bodyweight. This study aimed to identify the MC4R gene diversity in the second cross generation of Belgian Blue, Wagyu, and Brahman crossbred and its relationship with the body weight and size birth. Polymerase Chain Reaction (PCR) and DNA sequencing were used to identify Single Nucleotide Polymorphism (SNP). The result of this study showed that MC4R genes was polymorphic with one SNP at 1133 C>G and included missense mutation. SNP 1133 C>G has two of allels C and G with three genotypes. Test of Hardy Weinberg equilibrium showed that the population of cattle was in equilibrium. The heterozigosity values showed that the population of cattle had a low diversity of genetics. The result of association showed that SNP 1133 C>G in MC4R Genes was not able to indicate the difference between the weight, body length, heart girth and wither’s height at birth. Based on this study, it can be concluded that the polymorphism of MC4R genes can only be used to distinguish cattle genotypes but cannot be used as the selection tools for body weight and size birth.
Related Links	https://knepublishing.com/index.php/KnE-Life/article/view/11831/19149
Starting Page	453
Ending Page	464
Page Count	12
ISSN	24130877
DOI	10.18502/kls.v0i0.11831
Journal	KnE Life Sciences
Conference Proceedings	The 3rd International Conference on Advance & Scientific Innovation (ICASI) – Life Sciences Chapter
Language	English
Publisher Date	2022-09-13
Access Restriction	Open
Subject Keyword	SNP. Crossbreed beef cattle Heterozigosity Diversity MC4R gene
Content Type	Text
Resource Type	Article
Subject	Agricultural and Biological Sciences

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