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| Content Provider | Journal of Biological Chemistry (JBC) |
|---|---|
| Author | Darboux, Isabelle Lingueglia, Eric Champigny, Guy Coscoy, Sylvie Barbry, Pascal Lazdunski, Michel |
| Abstract | Amiloride-sensitive sodium channels have been implicated in reproductive and early developmental processes of several species. These include the fast block of polyspermy inXenopus oocytes that follows the sperm binding to the egg or blastocoel expansion in mammalian embryo. We have now identified a gene called dGNaC1 that is specifically expressed in the gonads and early embryo in Drosophila melanogaster. The corresponding protein belongs to the superfamily of cationic channels blocked by amiloride that includesCaenorhabditis elegans degenerins, the Helix aspersa FMRF-amide ionotropic receptor (FaNaC), the mammalian epithelial Na+ channel (ENaC), and acid-sensing ionic channels (ASIC, DRASIC, and MDEG). Expression of dGNaC1 inXenopus oocytes generates a constitutive current that does not discriminate between Na+ and Li+, but is selective for Na+ over K+. This current is blocked by amiloride (IC50 = 24 μm), benzamil (IC50 = 2 μm), and ethylisopropyl amiloride (IC50 = 49 μm). These properties are clearly different from those obtained after expression of the previously cloned members of this family, including ENaC and the human αENaC-like subunit, δNaC. Interestingly, the pharmacology of dGNaC1 is not very different from that found for the Na+ channel characterized in rabbit preimplantation embryos. We postulate that this channel may participate in gametogenesis and early embryonic development inDrosophila. |
| Related Links | http://www.jbc.org/content/273/16/9424.abstract |
| Ending Page | 9429 |
| Starting Page | 9424 |
| Page Count | 6 |
| File Format | HTM / HTML PDF |
| ISSN | 00219258 |
| Journal | Journal of Biological Chemistry (JBC) |
| Issue Number | 16 |
| Volume Number | 273 |
| DOI | 10.1074/jbc.273.16.9424 |
| e-ISSN | 1083351X |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 1998-04-17 |
| Access Restriction | Open |
| Subject Keyword | MEMBRANES AND BIOENERGETICS |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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