NDLI: Hypertonic Saline Resuscitation in a Porcine Model of Severe Hemorrhagic Shock

Content Provider	JAMA Network
Author	Stanford, Gregory G. Patterson, C. Richard Payne, Lynda Fabian, Timothy C.
Copyright Year	1989
Abstract	• The purpose of this study was to investigate the effect of 7.5% hypertonic saline solution ( HTS) as the initial solution in resuscitation of a pig in shock. Twenty-two animals were bled 50% of their blood volume over 30 minutes and maintained in shock for 60 minutes. The 14 survivors were divided into two groups. The first group was given 20 m: L/kg of lactated Ringer's solution ( LR) over a ten-minute period, while the second group was given 10 m: L/kg of HTS. Both groups were then given LR at 2 m: L/kg/min until the mean arterial pressure reached 80 mm Hg. The HTS group achieved a more rapid rise in mean arterial pressure over the first ten minutes of resuscitation. During this period, the cardiac index increased significantly more in the HTS group when compared with the LR group. All animals in the HTS group developed an adequate urine output. Only two animals in the LR group developed an adequate urine output. Hypertonic saline solution markedly improved survival, and there were significant improvements in hemodynamics. This was accomplished with smaller volumes of resuscitation fluid and may prove useful under conditions where intravascular access is limited.( Arch Surg1989;124:733-736)
Ending Page	736
Starting Page	733
Page Count	4
File Format	PDF HTM / HTML
ISSN	00040010
DOI	10.1001/archsurg.1989.01410060105022
Issue Number	6
Journal	Archives of Surgery
Volume Number	124
Language	English
Publisher	American Medical Association
Publisher Date	1989-06-01
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Surgery

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