NDLI: Cerium oxide nanoparticles protect primary osteoblasts against hydrogen peroxide induced oxidative damage

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Cerium oxide nanoparticles protect primary osteoblasts against hydrogen peroxide induced oxidative damage

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Volume 9 (2014) : Issue 1, Jan

The Journal of Engineering

Cerium oxide nanoparticles protect primary osteoblasts against hydrogen peroxide induced oxidative damage

Content Provider	IET Digital Library
Author	Zhou, Guoqiang Li, Yang Zheng, Baofeng Wang, Wenying Gao, Jing Wei, Haiying Li, Shenghui Wang, Shuxiang Zhang, Jinchao
Abstract	Oxidative damage is an important contributor to the morphological and the functional changes in the development of osteoporosis. In this reported work, the use of cerium oxide (CeO2) nanoparticles as a potential therapeutic agent for osteoporosis is explored. By using the primary osteoblasts (OBs) exposed to hydrogen peroxide (H2O2), it is shown that the CeO2 nanoparticles relieve the H2O2-induced oxidative damage. The protective effects of the CeO2 nanoparticles were because of a reduction in the reactive oxygen species (ROS). The level of the antioxidant enzymes was increased after treatment with the CeO2 nanoparticles in the OBs exposed to H2O2. Moreover, the cell apoptosis rate was decreased after treatment with the CeO2 nanoparticles. The CeO2 nanoparticles protect the OBs against the H2O2-induced oxidative damage, suppression of the antioxidant enzymes depletion and cell apoptosis via its ROS scavenging mechanism. The findings suggest that the CeO2 nanoparticles may have a potentially therapeutic value for the diseases related to the ROS.
Starting Page	91
Ending Page	96
Page Count	6
Volume Number	9
e-ISSN	17500443
Issue Number	Issue 2, Feb (2014)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/mnl/9/2
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/mnl.2013.0586
Journal	Micro & Nano Letters
Publisher Date	2014-02-19
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Antioxidant Enzyme Depletion Biochemistry Biomedical Material Cell Apoptosis Rate Cellular Biophysics CeO2 Cerium Compounds Cerium Oxide Nanoparticles Diseases Enzymes Functional Changes H2O2 Hydrogen Compound Hydrogen Peroxide Molecular Biophysics Morphological Changes Nanomedicine Nanoparticle Nanotechnology Application in Biomedicine Osteoporosis Oxidative Damage Patient Care And Treatment Patient Treatment Physical Chemistry of Biomolecular Solutions And Condensed State Primary Osteoblast Protection Reactive Oxygen Species ROS Scavenging Mechanism Therapeutic Agent
Content Type	Text
Resource Type	Article

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